The use of Acellular Dermal Matrix (Dermacell) in diabetic chronic wounds
1 Department of Vascular Surgery, Athens Medical Center, Greece.
2 Department of Biotechnology, University of Padua; Consultant Surgeon; Italy.
3 U.O. Geriatry, Department of Diabetology, Santa Maria del Carmine Hospital, Rovereto, Italy.
Review
International Journal of Scientific Research Updates, 2025, 09(01), 001-011.
Article DOI: 10.53430/ijsru.2025.9.1.0023
Publication history:
Received on 27 December 2024; revised on 02 February 2025; accepted on 05 February 2025
Abstract:
The extracellular matrix (ECM) is an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner. Components of the ECM link together to form a structurally stable composite, contributing to the mechanical properties of tissues. The ECM is also a reservoir of growth factors and bioactive molecules. It is a highly dynamic entity that is of vital importance, determining and controlling the most fundamental behaviors and characteristics of cells such as proliferation, adhesion, migration, polarity, differentiation, and apoptosis.[1][2]
The ECM provides a structural scaffold via a network of protein–protein and protein–proteoglycan interactions. These interactions are involved in the formation of supramolecular assemblies such as collagen fibrils and elastic fibers, in tissue architecture, and in cell-matrix interactions that regulate cell growth and behavior.
The cells and the ECM have a two-way reciprocal relationship.[3][4] Cells produce, secrete, deposit, and remodel ECM to mediate ECM composition and topography. The ECM in turn transmits signals through ECM receptors to influence cell characteristics and activities.[5] Such a feedback mechanism is essential for rapid response of cells to surrounding environmental changes.
Human acellular dermal matrices (ADMs) are used successfully in a variety of procedures, including sports medicine related, wound repair, and breast reconstructions,
Current treatment strategies for skin wounds/tissue support mostly aim to replace lost tissue rather than support intrinsic self-healing mechanisms. However, new developments within the area of tissue-engineered scaffolds are leading to an ultimate goal of tissue regeneration rather than replacement.[6][7][8][9][14][15]
Keywords:
Dermacell; ADM; Wound Healing; Diabetes; Chronic Wounds; Skin Substitutes; Skin Dressings; Matrices
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0