Persistence exposure to toxic oil and gas flaring pollutants-mediated insulin resistance and hyperinsulinemia among populations in the Niger Delta
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria.
Research Article
International Journal of Scientific Research Updates, 2022, 03(2), 120–126.
Article DOI: 10.53430/ijsru.2022.3.2.0031
Publication history:
Received on 07 May 2022; revised on 12 June 2022; accepted on 14 June 2022
Abstract:
Environmental pollutants of oil and gas flaring are fast emerging major threats to the global health communities and environmental authorities; and also, an important source of morbidity and mortality. From purposively selected 94 volunteers exposed to toxic oil and gas flared pollutants in Ogoni land, Niger Delta, Nigeria, serum samples were used to evaluate possible association between non-communicable diseases (NCDs) and insulin resistance using C-peptide and Insulin kits. Volunteer’s age ranged 18 to 50 years, and were exclusively females resident consistently, in the various communities, in the order of 10 years and above. When compared to control, the outcomes of this study indicated high levels of insulin resistance, insulin, beta cell function, blood glucose of 78%, 76.2%, 71.6%, 52.5%with corresponding decrease in connecting peptide value of 43.2% was associated within creases in various physio-metabolic risk factors including low density lipoprotein, triglyceride, total cholesterol, high density lipoprotein and body mass index of 64.9%, 62.4%, 60.6%, 52.5% and 52% respectively in the exposed population to oil and gas flaring pollutants. Meanwhile, the prevalence of cardio-metabolic risk factor ratio (TG/HDL-C) was higher for the exposed population (63.6 %.) than the control (36.4%); while the prevalence of hyperinsulinemia/insulin resistance showed age and time dependent increase of exposure. This study validates both insulin resistance and toxic pollutions of oil and gas flaring as sensitive indicators of multiple metabolic abnormalities. Further, the inherent capacity of toxic oil and gas flared pollutants to elicit detectable pathologies in various tissues and organ induced-insulin resistance, might plausibly be the mechanist-link, in metabolic derangements, in the development and progression of a number of chronic non-communicable diseases, including diabetes, dyslipidaemia, hypertension, cardiovascular diseases, cancers, respiratory diseases, obesity and complications and disabilities and even death.
Keywords:
Insulin Resistance; Hyperinsulinemia; Non-Communicable Disease; Ogoni; Inorganic Toxic Pollutants; Environmental Pollution-Centered Hypothesis
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