Antibacterial potency of Vernonia amygdalina on antibiotic-resistant non-typhoidal salmonella isolates from human and animal sources in southern Taraba, North-East, Nigeria
1 Department of Microbiology, Federal University Wukari, Taraba State, Nigeria.
2 Primary Health Care Initiative, Africa.
Research Article
International Journal of Biology and Pharmacy Research Updates, 2022, 02(02), 001–006.
Article DOI: 10.53430/ijbpru.2022.2.2.0035
Publication history:
Received on 02 October 2022; revised on 08 November 2022; accepted on 11 November 2022
Abstract:
Antibiotic discovery was considered a wonder of the world. Shortly after, many microorganisms began to exhibit resistance to prior antimicrobial actions of antibiotics. Notwithstanding, Quinones, Flavonoids, Flavones, Flavonols, Tannins, and Coumarins are major phytochemicals synthesized by plant parts and have shown decisive antimicrobial activities against a panel of microorganisms. In this research hot and cold extracts of fresh and dried Vernonia, amygdalina showed remarkable in vivo antimicrobial activity on antibiotic-resistant Salmonella isolates from various poultry farms and food vendors in Ibi, Donga, Takum, and Wukari. 5 g-10 ml, 10 g-10 ml, 15g-10ml, 20g-10ml, and 25g-10ml are arrays of Vernonia Amygdalina concentrations tested on the inocula. Significant light growth was observed for both menstruum extracts of dried and fresh leaves of Vernonia Amygdalina at higher concentrations levels of 20g-10ml, 25g-10ml, while and moderate growth was seen at lower concentrations levels of 5g-10ml, 10g-10ml. Also, heavy growth of Salmonella was detected in the control plates inoculated with the test microorganism but without the addition of any extracts. Weak political will in implementing regulation policies, funding of research, and perceived antimicrobial resistance to plant extracts as well as acceptability and cultural factors have threatened the extensive use of plant extract in the management of health. Improved universal health coverage and enhanced economic potentials are core benefits of the use of plant extracts for health management. Conclusively, plant extracts possess appreciable antimicrobial activities against Multi-Drug Resistance (MDR) microorganisms compared to currently prescribe synthetic drugs. Hence, further studies on clinical efficacy trials and the safety of more plants need to be intensified.
Keywords:
Bitter leaf; Non-Typhoidal Salmonella (NTS); Phytochemicals; Plant Extract; Salmonella; Vernonia amygdalina
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