The use of acellular dermal matrix in the closure of anterior leg ulceration with exposed tibialis anterior tendon caused by compression dressing
1 Department of Biotechnology, University of Padua, Italy.
2 U.O. Geriatry - Diabetology, Santa Maria del Carmine Hospital, Rovereto, Italy.
Review
International Journal of Biology and Pharmacy Research Updates, 2022, 02(01), 001–005.
Article DOI: 10.53430/ijbpru.2022.2.1.0029
Publication history:
Received on 16 June 2022; revised on 20 July 2022; accepted on 22 July 2022
Abstract:
The extracellular matrix (ECM) plays an integral role in wound healing. It provides both structure and growth factors that allow for the organised cell proliferation. Large or complex tissue defects may compromise host ECM, creating an environment that is unfavourable for the recovery of anatomical function and appearance. Bioscaffolds derived from the extracellular matrix (ECM) of decellularized tissues can naturally mimic the complex extracellular microenvironment through the retention of compositional, biomechanical, and structural properties specific to the native ECM. Increasingly, studies have investigated the use of ECM-derived scaffolds as instructive substrates.
Keywords:
Wound Healing; Diabetes; Chronic Wounds; Skin Substitutes; Skin Dressings; Matrices; ADM; p-Toluensulfonic acid; Biofilm
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